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Cannabis effekter mot illamående, ny undersökning ute!
Science: THC reinforced the anti-emetic effects of ondansetron in
animal studyThe 5-HT3 antagonists, such as ondansetron, are regarded as the
most effective drugs to treat cancer chemotherapy induced
nausea and vomiting. The natural cannabinoids THC and CBD
(cannabidiol) are also known to inhibit these symptoms. The
relative and combined effectiveness of these drugs in suppressing
vomiting produced by cisplatin was investigated in shrews.
Cisplatin is a chemotherapeutic agent that causes severe emesis.Researchers of the Wilfrid Laurier University in Waterloo,
Canada, demonstrated that ondansetron and THC both dose-
dependently suppressed cisplatin-induced vomiting and retching in
shrews. Furthermore, a combined pre-treatment of doses of the
two drugs that
were ineffective alone completely suppressed vomiting and
retching. CBD produced
a biphasic effect, suppressing vomiting at low doses and
increasing it at high doses.In two earlier clinical studies by Artim and DiBella (1983) and
Lane and colleagues (1991) THC increased the anti-emetic effect
of prochlorperazine in humans who underwent chemotherapy.
The new animal study shows that cannabinoids may help to
suppress nausea and vomiting that are not controlled by 5-HT3
antagonists alone.(Source: Kwiatkowska M, Parker LA, Burton P, Mechoulam R.
A comparative analysis of the potential of cannabinoids and
ondansetron to suppress cisplatin-induced emesis in the Suncus
murinus (house musk shrew). Psychopharmacology (Berl) 2004
Jan 22, [electronic publication ahead of print])Källa: IACM Bulletin 1 Feb 04
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1 Reply
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Tackar tackar! Det här var intressant. Särskilt notisen om CBD, där höga doser faktiskt framkallar kräkningar i stället för att hindra! Tackar Ashtray!